Venlafaxine

Venlafaxine

Psychiatric Prescription only ATC code: N06AX16

Prescription status is set country by country — the label where you live is the one that applies.

Beta: the medication section is still being tested, and its data may contain errors. Do not rely on it for a decision about your own treatment.

What it is

Venlafaxine is a serotonin and noradrenaline reuptake inhibitor. It blocks the reuptake of both transmitters, so more of each remains available at the synapse, with the noradrenergic effect becoming more prominent as the dose rises. It is used in depression and in anxiety disorders.

Typical dose
37.5–225 mg
1× a day
Times
With food
Morning

A usual adult range, not a national label — the dose and the timing differ by country and by product.

Used for

  • Depression
  • Anxiety

Approved uses differ by country — some of these may be off-label or unapproved where you live.

What to know while taking it

It is taken with food, usually in the morning, and the therapeutic effect builds over weeks. Blood pressure can rise, more so at higher doses, so it is monitored before and during treatment; light-headedness on standing can also occur, and blood sodium can drop and is worth monitoring. Sumatriptan and tramadol both add serotonergic activity on top of it, and tramadol additionally lowers the seizure threshold. Missed doses are felt quickly with this drug, so it is not stopped abruptly and changes are made with the prescriber.

When to see a doctor

Fainting or persistent dizziness on standing, and confusion, weakness or unsteadiness that could reflect low sodium, should be assessed. Agitation with fever, sweating, tremor or a fast heartbeat after adding a triptan or tramadol, and severe dizziness or electric-shock sensations after stopping, are reasons to see a doctor.

Worth knowing

  • Do not stop abruptly
  • Can raise blood pressure
  • Withdrawal symptoms on stopping

Interacts with

Markers to watch

Reference information, not medical advice. Discuss any change with your doctor.