Sertraline
Sertraline is a selective serotonin reuptake inhibitor. It blocks the transporter that returns serotonin into the nerve cell, leaving more of it available in the synapse, and over time this shifts mood and anxiety regulation. It is prescribed for depression and for anxiety disorders.
It is taken with food, generally in the morning, and it takes weeks before the benefit is clear — the early days can feel worse rather than better, which is not a sign it is failing. It should never be stopped abruptly, as discontinuation symptoms follow; any change belongs with the prescriber. Combining it with ibuprofen or acetylsalicylic acid adds to bleeding risk, tramadol and sumatriptan add serotonergic load, and fluoxetine is to be avoided altogether. Sodium can fall, particularly in older people, and liver enzymes such as ALT are worth watching, so both are checked from time to time.
Confusion, marked drowsiness, headache or unsteadiness can signal low sodium; agitation with fever, sweating, tremor or a racing heart can signal serotonin excess. Unusual bruising or bleeding, yellowing of the skin, or thoughts of self-harm mean see a doctor without delay.
Reference information, not medical advice. Discuss any change with your doctor.