Paroxetine

Paroxetine

Psychiatric Prescription only ATC code: N06AB05

Prescription status is set country by country — the label where you live is the one that applies.

Beta: the medication section is still being tested, and its data may contain errors. Do not rely on it for a decision about your own treatment.

What it is

Paroxetine is a selective serotonin reuptake inhibitor. It blocks the serotonin transporter so that more serotonin remains in the synapse, and with continued use this changes how mood and anxiety circuits respond. It is used in depression and in anxiety disorders.

Typical dose
10–40 mg
1× a day
Times
With food
Morning

A usual adult range, not a national label — the dose and the timing differ by country and by product.

Used for

  • Depression
  • Anxiety

Approved uses differ by country — some of these may be off-label or unapproved where you live.

What to know while taking it

It is usually taken in the morning, with or without food, and the effect develops gradually rather than at once. Weight gain is more common with paroxetine than with other SSRIs. It is a strong inhibitor of a liver enzyme that clears several other medicines, so metoprolol can accumulate and slow the pulse or lower blood pressure more than expected, while ibuprofen and related anti-inflammatories combined with an SSRI raise the risk of bleeding from the stomach. Of the SSRIs it has the most pronounced withdrawal profile, so it is not stopped abruptly; any change is planned with the prescriber.

When to see a doctor

A markedly slow pulse, dizziness on standing or breathlessness while also taking metoprolol should be checked. Black or bloody stools, vomited blood, or dizziness, electric-shock sensations and severe restlessness after doses have been missed are reasons to see a doctor.

Worth knowing

  • Do not stop abruptly
  • Withdrawal symptoms on stopping
  • Can change body weight

Interacts with

Reference information, not medical advice. Discuss any change with your doctor.