Escitalopram

Escitalopram

Psychiatric Prescription only ATC code: N06AB10

What it is

Escitalopram is a selective serotonin reuptake inhibitor. It prevents serotonin from being taken back up into the nerve cell that released it, increasing serotonergic signalling in a way that gradually alters mood and anxiety processing. It is prescribed for depression and anxiety disorders.

Typical dose
5–20 mg
1× a day
Times
Any time
Morning

Used for

  • Depression
  • Anxiety

What to know while taking it

Food does not matter, and it is generally taken in the morning; the benefit accumulates over weeks rather than days. It can lengthen the QT interval on the ECG, which matters more alongside other drugs that do the same or when heart rhythm is already a concern, and it can lower blood sodium, so that value is worth monitoring. Ibuprofen and acetylsalicylic acid together with an SSRI increase bleeding risk from the stomach lining, and sumatriptan adds a second serotonergic drug. It should not be stopped abruptly.

When to see a doctor

Fainting, palpitations or a sensation of the heart stumbling may reflect a rhythm effect and should be assessed promptly. Confusion, weakness, nausea or unsteadiness can signal low sodium, and bleeding from the gut or agitation with fever and tremor after a new serotonergic drug are also reasons to see a doctor.

Worth knowing

  • Do not stop abruptly
  • Takes weeks to work
  • Can prolong the QT interval
  • Can lower sodium

Markers to watch

Reference information, not medical advice. Discuss any change with your doctor.