Rosuvastatin

Rosuvastatin

Lipid-lowering Prescription only ATC code: C10AA07

Prescription status is set country by country — the label where you live is the one that applies.

Beta: the medication section is still being tested, and its data may contain errors. Do not rely on it for a decision about your own treatment.

What it is

Rosuvastatin is a statin that blocks HMG-CoA reductase, the enzyme that controls the rate of cholesterol production in the liver. The liver responds by pulling more LDL cholesterol out of the blood. It is used to lower cholesterol and to reduce the long-term risk of stroke and other cardiovascular events.

Typical dose
5–40 mg
1× a day

A usual adult range, not a national label — the dose and the timing differ by country and by product.

Used for

  • Cholesterol
  • Stroke prevention

Approved uses differ by country — some of these may be off-label or unapproved where you live.

What to know while taking it

It can be taken with or without food, and at any time of day: it stays in the body long enough that it need not be timed to the night-time peak in cholesterol production, the way shorter-acting statins are, so a fixed daily time matters more than which time. LDL and total cholesterol show whether it is working, while ALT is watched for liver strain and creatinine and HbA1c are followed because statins can nudge both. It adds to the effect of the anticoagulant warfarin, so clotting needs rechecking, and combining it with fenofibrate raises the risk of muscle injury. Statins deplete coenzyme Q10. It is not used in pregnancy, as cholesterol is needed for fetal development.

When to see a doctor

Unexplained muscle pain, tenderness or weakness — especially with dark urine or fever — needs prompt medical assessment, as does yellowing of the skin or eyes or persistent nausea. A planned or discovered pregnancy is a reason to see a doctor rather than simply carrying on.

Worth knowing

  • Report unexplained muscle pain
  • Watch liver enzymes
  • Not during pregnancy

Interacts with

Markers to watch

Nutrients affected

  • coq10 — depleted by

Reference information, not medical advice. Discuss any change with your doctor.