Rosuvastatin

Rosuvastatin

Lipid-lowering Prescription only ATC code: C10AA07

What it is

Rosuvastatin is a statin that blocks HMG-CoA reductase, the enzyme that controls the rate of cholesterol production in the liver. The liver responds by pulling more LDL cholesterol out of the blood. It is used to lower cholesterol and to reduce the long-term risk of stroke and other cardiovascular events.

Typical dose
5–40 mg
1× a day
Times
Any time
Evening

Used for

  • Cholesterol
  • Stroke prevention

What to know while taking it

It can be taken with or without food, and evening dosing fits the body's own cholesterol production cycle. LDL and total cholesterol show whether it is working, while ALT is watched for liver strain and creatinine and HbA1c are followed because statins can nudge both. It adds to the effect of warfarin, so clotting needs rechecking, and combining it with fenofibrate raises the risk of muscle injury. Statins deplete coenzyme Q10. It is not used in pregnancy, as cholesterol is needed for fetal development.

When to see a doctor

Unexplained muscle pain, tenderness or weakness — especially with dark urine or fever — needs prompt medical assessment, as does yellowing of the skin or eyes or persistent nausea. A planned or discovered pregnancy is a reason to see a doctor rather than simply carrying on.

Worth knowing

  • Report unexplained muscle pain
  • Watch liver enzymes
  • Not during pregnancy

Interacts with

Markers to watch

Nutrients affected

  • coq10 — depleted by

Reference information, not medical advice. Discuss any change with your doctor.