Levofloxacin

Levofloxacin

Antibiotics Prescription only ATC code: J01MA12

What it is

Levofloxacin is a fluoroquinolone antibiotic. It blocks the bacterial enzymes that unwind and reseal DNA during replication, so susceptible bacteria cannot divide. It is prescribed for bacterial infections; it has no effect on viral illness.

Typical dose
250–750 mg
1× a day
Times
On an empty stomach

Used for

  • Bacterial infection

What to know while taking it

It can be taken with or without food, but is kept apart in time from dairy, antacids and mineral supplements, since calcium, iron and magnesium bind the drug in the gut and blunt absorption — the same binding means these minerals are less available while the course runs, and probiotics are spaced apart so the antibiotic does not simply kill them. Skin becomes more sensitive to strong sun during treatment. It can raise the effect of warfarin, and it can shift blood glucose in either direction, which is why creatinine, ALT and glucose may be checked, and why it is worth mentioning metformin and any warfarin use to the prescriber. The full course is finished as prescribed, even once symptoms settle, because stopping early selects for resistant bacteria.

When to see a doctor

New pain, swelling or a snapping sensation in a tendon, especially the heel, means stop guessing and see a doctor, as tendon damage is a rare but real effect. Fainting, palpitations or an irregular heartbeat (the drug can prolong the QT interval), unusual bruising or bleeding, yellowing skin, or symptoms of very low or very high blood sugar also warrant medical review.

Worth knowing

  • Rare tendon damage
  • Separate from dairy
  • Avoid strong sun
  • Can prolong the QT interval
  • Finish the full course

Markers to watch

Nutrients affected

  • calcium — absorption blocked with (Calcium, ionized, Calcium, total, Ferritin)
  • iron — absorption blocked with (Ferritin, Hematocrit, Hemoglobin)
  • magnesium — absorption blocked with (Glucose, HOMA-IR, Magnesium)

Reference information, not medical advice. Discuss any change with your doctor.