Levetiracetam

Levetiracetam

Neurological Prescription only ATC code: N03AX14

What it is

Levetiracetam is an antiseizure drug that binds the synaptic vesicle protein SV2A and damps down the excessive neuronal firing that drives seizures. Unlike older agents it has little effect on liver enzymes, so it interacts with few other medicines. It is used to treat epilepsy, alone or alongside another antiseizure drug.

Typical dose
250–1500 mg
2× a day

Used for

  • Epilepsy

What to know while taking it

Food makes no difference, so the tablet fits around meals either way; keeping the timing steady from day to day matters more than what it is taken with. The kidneys clear the drug almost unchanged, which is why creatinine and eGFR are followed and why reduced kidney function calls for a review of the amount taken. White blood cells are checked because levetiracetam can lower them. The most common problem is behavioural: irritability, low mood, agitation or a flatter emotional tone, sometimes noticed by people around the person rather than by the person taking it. Stopping suddenly can trigger seizures, including in people who have been seizure-free for a long time, so any change is planned with the prescriber.

When to see a doctor

Marked mood change, unusual aggression, depression or thoughts of self-harm are reasons to see a doctor promptly rather than wait it out. Repeated infections, fever or unexplained bruising, and any rash, also warrant a check.

Worth knowing

  • Watch for mood changes
  • Do not stop abruptly

Markers to watch

Reference information, not medical advice. Discuss any change with your doctor.