L-Glutamine

L-Glutamine

Supplements Over the counter

Prescription status is set country by country — the label where you live is the one that applies.

Beta: the medication section is still being tested, and its data may contain errors. Do not rely on it for a decision about your own treatment.

What it is

L-Glutamine is an amino acid the body normally makes for itself, and which becomes conditionally essential when illness, injury or heavy training raise demand for it. It is the main fuel for the cells lining the gut and for rapidly dividing immune cells, which is the reasoning behind its use as a supplement. It is taken for immune support and for digestive complaints.

Typical dose
5–10 g
1× a day

A usual adult range, not a national label — the dose and the timing differ by country and by product.

Used for

  • Immune support
  • Digestion

Approved uses differ by country — some of these may be off-label or unapproved where you live.

What to know while taking it

It dissolves in water and its absorption does not depend on meals, so it can be taken with food or without. In the body it is broken down to glutamate and ammonia, which the liver has to clear; that is why the liver enzymes ALT and AST are the values worth following on a routine blood panel, especially where liver function is already impaired. Glutamine standing in solution slowly degrades, so the powder is mixed shortly before it is used rather than prepared in advance.

When to see a doctor

Yellowing of the skin or eyes, persistent nausea, dark urine or unexplained confusion point to the liver rather than the gut and mean it is time to see a doctor. A rise in ALT or AST that holds on a repeat test is the same signal in numbers.

Worth knowing

  • Watch liver enzymes

Markers to watch

Reference information, not medical advice. Discuss any change with your doctor.