Ezetimibe

What it is

Ezetimibe is a lipid-lowering drug that works in the small intestine rather than the liver. It blocks the transporter that absorbs cholesterol from food and bile, so less cholesterol reaches the bloodstream and the liver pulls more of it out of circulation. It is prescribed to lower cholesterol, either on its own or alongside a statin when LDL remains above target.

Used for

• Cholesterol

What to know while taking it

It can be taken with or without food, and at whatever time of day is easiest to remember consistently, since the effect depends on steady daily use rather than timing. The point of the treatment is visible only in bloodwork, so LDL cholesterol is checked to judge whether it is working. ALT is followed as well, because liver enzymes can rise, particularly when the drug is combined with a statin.

When to see a doctor

Persistent tiredness, loss of appetite, dark urine or yellowing of the skin or eyes suggest a liver problem and are reasons to see a doctor rather than wait for the next scheduled test.

Markers to watch

• LDL cholesterol
• ALT