Domperidone

Domperidone

Digestive Over the counter ATC code: A03FA03

What it is

Domperidone is a prokinetic and anti-nausea drug that blocks dopamine receptors in the gut wall and in the chemoreceptor trigger zone, the part of the brainstem that sits outside the blood-brain barrier. The result is faster stomach emptying and a suppressed vomiting reflex. It is used for nausea and for sluggish digestion with fullness and bloating.

Typical dose
10 mg
3× a day
Times
On an empty stomach

Used for

  • Nausea
  • Digestion

What to know while taking it

It is taken before meals on an empty stomach, since it works by moving food along and needs to be acting already while the meal is being emptied; food taken first delays its absorption. It can prolong the QT interval, the heart's electrical recovery time, so it is meant for short courses and combines badly with other QT-prolonging drugs and with medicines that slow its breakdown in the liver, such as certain antifungals and antibiotics. Any existing heart rhythm problem or potassium or magnesium disturbance makes it a poorer choice.

When to see a doctor

Palpitations, fainting, dizziness, an irregular heartbeat, or nausea that persists past a short course are reasons to see a doctor.

Worth knowing

  • Can prolong the QT interval
  • Short courses only

Reference information, not medical advice. Discuss any change with your doctor.