Curcumin

What it is

Curcumin is the main yellow pigment of turmeric root, used as a plant-derived supplement. It interferes with several inflammatory signalling pathways in the body, which is the basis for its use in the context of inflammation and joint complaints. It is also a poorly absorbed molecule, so how it is taken matters more than with most supplements.

Used for

• Inflammation
• Joints

What to know while taking it

Curcumin dissolves in fat rather than water, so it is taken with a meal that contains some fat, which improves how much reaches the bloodstream. It has a mild antiplatelet effect and can add to the bleeding risk of blood thinners such as warfarin and clopidogrel, which is why it is not combined with them without medical advice. Curcumin also stimulates the gallbladder to contract, so it is used with caution where gallstones are known or suspected, and it is worth pausing before planned surgery or dental work after discussing this with a doctor.

When to see a doctor

Unusual bruising, bleeding gums, nosebleeds, or black or bloody stools while taking curcumin mean seeing a doctor promptly. So does severe pain in the upper right abdomen, especially after a fatty meal, or yellowing of the skin or eyes.

Worth knowing

• Absorbed better with fat
• Raises bleeding risk
• Caution with gallstones