Clindamycin

Clindamycin

Antibiotics Prescription only ATC code: J01FF01

What it is

Clindamycin is a lincosamide antibiotic. It binds the bacterial ribosome and blocks protein synthesis, which stops susceptible bacteria from multiplying. It is used for bacterial infections, including infections of the skin and soft tissue.

Typical dose
150–450 mg
4× a day
Times
With food

Used for

  • Bacterial infection
  • Skin

What to know while taking it

It is swallowed upright with plenty of water, because a capsule that lodges in the oesophagus can irritate it. Clindamycin suppresses normal gut flora as well as the target bacteria, so probiotics are usually spaced a few hours away from it rather than swallowed at the same time. The full course is finished as prescribed, because stopping early leaves the less susceptible bacteria behind. Liver enzymes such as ALT can rise during treatment, so they are sometimes checked.

When to see a doctor

Severe, watery or bloody diarrhoea, during the course or in the weeks after it ends, is the classic sign of antibiotic-associated colitis and is a reason to see a doctor rather than treat it at home. Yellowing of the skin or eyes, marked abdominal pain, or a rash with swelling also warrant medical assessment.

Worth knowing

  • Watch for severe diarrhoea after the course
  • Finish the full course
  • Take probiotics a few hours apart

Interacts with

Markers to watch

Reference information, not medical advice. Discuss any change with your doctor.