Acetylcysteine

Acetylcysteine

Respiratory Over the counter ATC code: R05CB01

What it is

Acetylcysteine is a mucolytic: it breaks the disulfide bonds that hold thick mucus together, making secretions thinner and easier to clear from the airways. It is also a precursor of glutathione, the body's main detoxifying antioxidant, which is why it is used for liver support as well as for a productive cough.

Typical dose
200–600 mg
1× a day
Times
With food
Morning

Used for

  • Cough
  • Liver support

What to know while taking it

It is taken with food and usually in the morning, and it works only if fluid intake is adequate — thinned mucus still has to be coughed out, and water is what keeps it moving. It should be separated from antibiotics by a couple of hours, because the two can interact in the stomach and reduce how much antibiotic is absorbed. The taste and the sulfur smell are normal for the molecule; mild stomach upset is the most common complaint.

When to see a doctor

A cough that keeps getting worse rather than looser, fever, breathlessness or wheeze after a dose, or a rash means it is time to see a doctor rather than continue on one's own.

Worth knowing

  • Separate from antibiotics by 2 hours
  • Drink enough water

Reference information, not medical advice. Discuss any change with your doctor.